Adriamycin-induced, TNF-a-mediated central nervous system toxicity
نویسندگان
چکیده
Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand Department of Chemistry, Center of Membrane Sciences, and Sanders-Brown Center on Aging, 121 Chemistry-Physics Building, University of Kentucky, Lexington, KY 40506, USA Department of Physiology, University of Kentucky, Lexington, KY 40536, USA Department of Radiation Medicine, University of Kentucky, Lexington, KY 40536, USA
منابع مشابه
Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity.
The clinical effectiveness of adriamycin (ADR), a potent chemotherapeutic, is known to be limited by severe cardiotoxic side effects. However, the effect of ADR on brain tissue is not well understood. It is generally thought that ADR is not toxic to the brain because ADR does not pass the blood-brain barrier. The present study demonstrates that ADR autofluorescence was detected only in areas of...
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Adriamycin (ADR), a potent anti-tumor agent, produces reactive oxygen species (ROS) in cardiac tissue. Treatment with ADR is dose-limited by cardiotoxicity. However, the effect of ADR in the other tissues, including the brain, is unclear because ADR does not pass the blood-brain barrier. Some cancer patients receiving ADR treatment develop a transient memory loss, inability to handle complex ta...
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تاریخ انتشار 2006